Jean-Denis Docquier

Jean-Denis Docquier

Italy
University of Siena
Associate Professor of Microbiology

Dr. Docquier received an extensive training in both biochemistry and microbiology, and developed research projects focused on the molecular study of antibiotic mechanism of action and resistance, with a peculiar focus on β-lactamases, which he has been studying for over 20 years. He is an Associate Professor of Microbiology and teaches various aspects of Microbiology (including molecular microbiology, applied and pharmaceutical microbiology, and microbiology for drug discovery) to Chemistry, Pharmacy and Biotechnology students.

His research activities mainly focus (a) on the study of the molecular aspects of bacterial resistance to antibiotics, and (b) on the functional and structural characterization of β-lactamases, most importantly metallo-β-lactamases and serine-β-lactamases showing carbapenemase activity, as effectors of β-lactam resistance in clinically-relevant bacterial Gram-negative pathogens and as targets for enzyme inhibitors, and more recently, (c) on the discovery, optimization and characterization of novel compounds with antimicrobial properties.