The complex interactions between the microbiome, the epithelial barrier, immune cells and drug metabolism are critical for protection from disease. The focus of the Klatt lab is to understand mechanisms underlying mucosal dysfunction, microbiome dysbiosis, drug metabolism, and altered immunity in mucosal tissues (mainly gastrointestinal and female reproductive tracts), and how these defects contribute to HIV transmission and pathogenesis. Our ultimate goal is to improve prevention and treatment strategies for HIV infection.
Nikki Klatt is an associate professor in the department of Pharmaceutics at the University of Washington, and adjunct assistant professor in the programs in Pathobiology in the school of global health and the molecular and cellular biology graduate program. Nikki is also director of the mucosal immunology core of the Washington National Primate Research Center.
Nikki received her PhD in Immunology and Molecular Pathogenesis from Emory University in Atlanta, GA in 2009, and she also studied as a visiting fellow at the University of Pennsylvania in Philadelphia, PA from 2006-2008. She completed her postdoctoral training at the NIH in 2012, in the Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases in Bethesda, MD.